WEDNESDAY, might twenty three (Health Product Portal News) -- It's long been known that a high-fat, low-carbohydrate diet will cut back epileptic seizures that resist drug therapy, and currently researchers finding out mice say they suppose they understand why.
The results of their analysis in mice counsel that resistance to seizures among those that eat what is known as a ketogenic diet is linked to a protein that modifies cellular metabolism within the brain.
The findings, reported within the might twenty four issue of the journal Neuron, might cause the event of recent treatments for epilepsy, consistent with the researchers at Dana-Farber Cancer Institute and Harvard Medical college in Boston.
"The affiliation between metabolism and epilepsy has been such a puzzle," study co-leader Gary Yellen, a professor of neurobiology at Harvard Medical college, said in a very Harvard news unharness. "I've met lots of youngsters whose lives are fully modified by this diet. It's amazingly effective, and it works for several youngsters for whom medication do not work."
In tests with mice, the researchers found that modifying the BCL-2-associated agonist of cell death protein led to altered brain metabolism and guarded against seizures.
"Diet looks like this wholesome thanks to treat seizures, however it's totally arduous. I mean, diets generally are arduous, and this diet is admittedly arduous," Yellen said. "So finding a pharmacological substitute for this is able to create millions of folks very happy."
While the findings hold promise, consultants note that analysis involving animals frequently fails to guide to advantages for humans.
The Epilepsy Foundation has a lot of regarding the ketogenic diet.